Size-selected Core-shell Nanoalloys for Laser Desorption/ionization Detection of Small Metabolites

Sensitive and high throughput detection of small metabolites in human biofluid plays an important role in the diagnosis of diseases. Here we report a one-step synthesis of a kind of core-shell nanoalloy with tunable structures for LDI-MS detection of small metabolites. The optimized nanoalloy could detect small molecules in 1.0 microliter biofluid with direct LDI-MS method.