Synthesis of Thromboxane B3 and Its Direct Separation from Thromboxane B2 by Reversed-Phase High Performance Liquid Chromatography.

The first chemical synthesis of thromboxane B3 starting with the Corey lactone is described. A reversed-phase high-performance liquid chromatographic method was developed for the direct determination without derivatization, of thromboxane B3 in the presence of thromboxane B2.