Research progress of glutaminase in tumor

Glutamine (Gln) metabolism has been found to play an important role in tumor growth, and glutaminase (GA) in mitochondria has been a hotspot in recent years as a key enzyme in the process of metabolism. It exists as two isoforms, originally identified as the kidney-typeglutaminase (GLS1) and liver-type glutaminase(GLS2), respectively. GLS1 is considered to be a potential oncogene, which high expression in varieties of tumor cells. The biological function of GLS2 is difference with GLS1, which gradually attracted the attention of many scholars. This article focuse on the research progress of glutaminase in tumor. Key words: Glutamine; Glutaminase; Tumor