Catalytic Asymmetric Reactions for Organic Synthesis: The Combined C−H Activation/Siloxy-Cope Rearrangement
2004
Tetrakis(N-[4-dodecylbenzenesulfonyl]-(l)-prolinate) dirhodium [Rh2(S-DOSP)4]-catalyzed decomposition of vinyldiazoacetates in the presence of allyl silyl ethers results in the formation of the direct C−H insertion product and the product derived from a combined C−H activation/siloxy-Cope rearrangement. Both products are formed with very high diastereoselectivity (>94% de) and high enantioselectvity (78−93% ee). Under thermal or microwave conditions, the direct C−H insertion product undergoes a siloxy-Cope rearrangement in a stereoselective manner.
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