In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET

Majken B. Thomsen,Jan Jacobsen,Thea P. Lillethorup,Anna C. Schacht,Mette Simonsen,Marina Romero-Ramos,David J. Brooks,Anne M. Landau

In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET

2020

Majken B. Thomsen
Jan Jacobsen
Thea P. Lillethorup
Anna C. Schacht
Mette Simonsen
Marina Romero-Ramos
David J. Brooks
Anne M. Landau

The number of functionally active synapses provides a measure of neural integrity, with reductions observed in neurodegenerative disorders. [11C]UCB-J binds to synaptic vesicle 2A (SV2A) transmembr...

Keywords:

SV2A
Neurodegeneration
Biology
Anesthesia
Synaptic vesicle
Synapse
Preclinical imaging
Neuroscience

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