Ellagic acid plays an important role in enhancing productive performance and alleviating oxidative stress, apoptosis in laying quail exposed to lead toxicity

Abstract Lead (Pb) is one of the most toxic heavy metal environmental pollutants due to its widespread use of the industry and it is a harmful substance for human and animal health. This study was conducted to investigate the potential protective effects of ellagic acid (EA) on performance, egg quality, antioxidant parameters, and apoptotic pathway proteins in laying quails exposed to Pb toxicity. A total of 168 (15-week old) laying quails (Coturnix coturnix Japonica) were divided into 6 experimental groups (with similar initial average body weight). Birds were fed 1 of 6 diets for 8 weeks: 1 – Control (basal diet), 2 – Pb (basal diet + 100 mg/kg Pb), 3 – EA-300 (basal diet + 300 mg/kg EA), 4 – EA-500 (basal diet + 500 mg/kg EA), 5 – Pb + EA-300 (basal diet + 100 mg/kg Pb + 300 mg/kg EA), 6 – Pb + EA-500 (basal diet + 100 mg/kg Pb + 500 mg/kg EA). The results showed that adding 100 mg/kg of Pb to basal diet was adversely affected the performance parameters and, feed intake and egg production were significantly decreased by Pb supplementation (P   0.05). Liver and kidney tissues of Pb group malondialdehyde (MDA) level increased (P