Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-β-glucosidase mutant that causes Gaucher disease

Marc N.Offman1,6, Marcin Krol2, Burkhard Rost1, Israel Silman3, Joel L.Sussman,4 and Anthony H.Futerman5 Institut fur Informatik/I12, Technische Universitat Munchen, Boltzmannstr 3, 85748 Garching b. Munchen, Germany, Department of Bioinformatics and Telemedicine, Jagiellonian University, Collegium Medicum, Lazarza 16, 31-531 Krakow, Poland, Departments of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel and Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel