Na+-Glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens

Abstract The methanol extract of Sophora flavescens , which is used in traditional Chinese medicine (sophorae radix), showed potent Na + -glucose cotransporter (SGLT) inhibitory activity. Our search for active components identified many well-known flavonoid antioxidants: kurarinone, sophoraflavanone G, kushenol K, and kushenol N.