Development of an anti-drug antibody assay to detect anti-drug antibodies to protein and PEG in a PEGylated molecule.

Yanqiu Liu,Nancy Yu,Mehraban Khosraviani,Eric Wakshull

Development of an anti-drug antibody assay to detect anti-drug antibodies to protein and PEG in a PEGylated molecule.

2020

Yanqiu Liu
Nancy Yu
Mehraban Khosraviani
Eric Wakshull

Background: PEGylation technology is one of long-acting delivery (LAD) platforms used to increase half-life of protein therapeutics. However, PEGylation of anti-Factor D Fab (PEG-aFD) poses challen...

Keywords:

Antibody
PEGylation
PEG ratio
Chemistry
Protein therapeutics
Pharmacology
Drug
Anti-Drug Antibody

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