X-RAY NANOPHOSPHORS BASED ON BaGdF5 FOR X-RAY PHOTODYNAMIC THERAPY IN ONCOLOGY

X-ray and gamma radiation can be used to expand the possibilities of photodynamic therapy in the treatment of deep-lying tumors. One of the promising materials for converting X-ray radiation to optical radiation is BaGdF5 nanoparticles doped with ions of rare-earth elements. It is shown that solvothermal synthesis and a technique using microwave radiation lead to the production of BaGdF5:Eu nanoparticles with similar characteristics; however, when using microwave radiation, the time of the synthesis decreases by at least an order of magnitude. Microwave-synthesized doped BaGdF5:Eu nanoparticles are biocompatible and in terms of size (6–14 nm) meet the requirements for the subsequent preparation of nanocomposites based on them with the optical photosensitizers necessary for X-ray photodynamic therapy.