Oxidative Asymmetric Umpolung Alkylation of Evans′ β-Ketoimides Using Dialkylzinc Nucleophiles.
2015
Umpolung alkylation of Evans’ auxiliary substituted β-ketoimides affords the diastereomerically pure products in yields ranging from 40 to 80%. The reaction itself proceeds with diastereoselectivities between 3 : 1 and 18 : 1. Dialkylzinc serves as the nucleophile and umpolung of the β-keto-imide enolate is achieved by the action of Koser's reagent.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
1
References
0
Citations
NaN
KQI