Influence of ornithine on albumin synthesis by fetal and neonatal hepatocytes maintained in culture
1987
Abstract Fetal rat as well as fetal and neonatal human hepatocytes were cultured in an arginine-free medium with or without l -ornithine. This amino acid was found greatly to improve cell survival of both rat and human parenchymal cells and to favour their proliferation. In addition, l -ornithine appeared to modulate the expression of various functions and particularly to increase albumin secretion. Since a correlated increase of the corresponding mRNA was observed, it may be postulated that l -ornithine acts at a pre-translational level.
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