Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation.
2004
Abstract In this manuscript, the synthesis and SAR evaluation of a novel pyrazinone class of tryptase inhibitors is described. Chemical optimization of the P1 and P4 groups led to the identification of 7p ( K i = 93 nM) as a potent inhibitor of mast cell tryptase.
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