The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis

How centrioles are amplified to produce multicilia is unclear, but a structure named the deuterosome has been implicated in the process. Zhu and colleagues demonstrate that Deup1, a paralogue to the centriole protein Cep63, governs deuterosome formation and mediates large-scale de novo centriole amplification in multiciliated cells.