Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application
2013
Abstract A fully automatized radiosynthesis of (+)- and (−)-[ 18 F]Flubatine ((+)- and (−)NCFHEB) by means of a commercially available synthesis module (TRACERlab FX FN) under GMP conditions is reported. Radiochemical yields of 30% within an overall synthesis time of 40 min were achieved in more than 70 individual syntheses. Specific activities were approximately 3000 GBq/μmol and radiochemical purity was determined to be at least 97%.
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