Synthesis and antiviral activity of novel methylene cyclopropyl nucleosides.

Novel exomethylene cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate5 was synthesized in 4 steps, from Feists acid1 and was condensed with purine derivatives by the SN2 type reaction to give some cyclopropyl nucleosides. The synthesized nucleosides did not showed any significant antiviral activity against HSV-1, HSV-2, HCMV, HIV-1, HIV-2, and HBV up to 100 μM.