Bicyclo[4.4.0]decane oxygenated sesquiterpenes from Eryngium maritimum essential oil.

Investigation of the essential oil of the aerial parts of Eryngium maritimum L. from Corsica led to the isolation of one known sesquiterpene (1) and three new oxygenated sesquiterpenes with a muurolane or cadinane skeleton (2–4). Structure assignments of 4βH-muurol-9-en-15-al (1), 4βH-cadin-9-en-15-al (2), 4βHmuurol-9-en-15-ol (3) and 4βH-cadin-9-en-15-ol (4) were carried out by GC/MS (EI and CI) and comprehensive 1D and 2DNMR spectroscopy. Antibacterial activity of Eryngium maritimum L. oil and column chromatography fractions have been investigated for the first time. The oxygenated fraction, which contains the four sesquiterpenes, was efficient against Listeria monocytogenes and Echerichia coli.