Role of Ezrin in Tumor Metastasis

The key to increasing the survival of patients with malignancies is to prevent and control tumor metastasis. Ezrin, as a linker between the plasma membrane and the cortical actin cytoskeleton of cells, regulates such cell activities as survival, adhesion and mobility of cells, which are closely related to tumorigenesis, progression and metastasis of malignant tumors by forming membrane-cytoskeleton complexes and specialized cell surface domains. Upregulated expression of Ezrin may contribute to tumor metastasis. This article reviews the role of Ezrin in tumor metastasis and the possible molecular mechanisms.