Factor xa inhibitors of clotting, production and use thereof.

Compound of general formula I (See formula) in which A is P2-P1 (see formula) and P2 comes from one of the following amino acids in the D-configuration: acid D-2,3-diaminopropionic acid D- 2,4-diaminobutyric, D-citrulline, D-homocitrulline, D-norcitrulina, D-arginine, D-homoarginine, D-norarginine, D-3-guanidinophenylalanine, D-3-guanidinofenilhomoalanina, D-3-guanidinofenilglicina, D- 3-amidinophenylalanine, D-3-amidinofenilhomoalanina, D-3-amidinophenylglycine, D-4-guanidinometilfenilalanina, D-4-guanidinometilfenilhomoalanina, D-4-guanidinometilfenilglicina, D-3-guanidinometilfenilalanina, D-3-guanidinometilfenilhomoalanina, D- 3-guanidinometilfenilglicina, D-3-amidinopiperidinilalanina, D-3-amidinopiperidinilhomoalanina, D-3-amidinopiperidinilglicina, n-butilamidinoglicina, n-pentilamidinoglicina, n-propilamidinoglicina, D-canavanine, D-ho-mocanavanina, D-norcanavanina acid, 2 -amino-4-amidinohidrazono-butyric acid, 2-amino-3-amidinohidrazono-propionic acid or 2-amino-5-amidinohidrazono-pentanoic acid, 2-amino-4- (pyridin-4-ylamino) -butyric acid, 2-amino- 4- (pyridin-4-ylamino) -propionic acid, 2-amino- 4- (pyridin-4-ylamino) -pentanoic acid, 4-imidazolyl-propargilgli-ce, D-histidine, D-homohistidine, D-histidine (1-methyl), D-homohistidina- (1-methyl), D histidine (3-methyl), D-homohistidina- (3-methyl), D-alanine (4- [5-2 (-amino) imidazoyl], D-homoalanine (4- [5-2 (-amino) imidazoyl I ], D-glycine (4- [5-2 (-amino) imidazoyl], D-alanine (3- (2-pyrimidinyl), D-homoalanine (3- (2-pyrimidinyl), D-alanine (3- ( 5-pyrimidinyl), D-homoalanine (3- (5-pyrimidinyl), acid D-2-amino-3- (2-amino-pyrimidin-5-yl) -propionic acid, D-2-amino- 4- ( 2-yl-amino-pyrimidin-5-) -butyric acid, D-alanine (3- (2-benzimidazolyl)), D-homoalanine (3- (2-benzimidazolyl)), D-tryptophan which is substituted aminoalkyl groups on the ring indole, D-homotryptophan is aminoalkyl substituted on the indole ring groups, acid D-2-amino-3- (6-amino-pyridin-3-yl) -propionic acid D-2-amino-4- (6-amino-pyridin-3-yl) butyric acid, D-2-amino-3- (6-amino-2-methylpyridin-3-yl) -propionic acid, D- 2-amino-4- (6-amino-2-methyl- pyridin-3-yl) butyric acid, D-2-amino-3- (6-amino-2,4-dimethyl-pyridin-3-yl) propionic acid D-2-amino-4- (6-amino- 2,4-dimethyl-pyridin-3-yl) butyric acid, D-3-hidroxiamidinofenilalanina, D-3-hydroxy-amidinofenilhomoalanina, D-3- hidroxiamidinofenilglicina; R1 is H or - (CH2) aCOOR6 with a = 0, 1, 2, 3, 4 or 5, and R6 is an alkyl branched or unbranched containing 1 to 6 carbon atoms; R2 is ...