Noncovalent Stabilization of Vesicular Polyion Complexes with Chemically Modified/Single-Stranded Oligonucleotides and PEG-b-guanidinylated Polypeptides for Intracavity Encapsulation of Effector Enzymes Aimed at Cooperative Gene Knockdown.

Beob Soo Kim,Mitsuru Naito,Hiroyuki Chaya,Mao Hori,Kotaro Hayashi,Hyun Su Min,Yu Yi,Hyun Jin Kim,Tetsuya Nagata,Yasutaka Anraku,Akihiro Kishimura,Kazunori Kataoka,Kanjiro Miyata

Noncovalent Stabilization of Vesicular Polyion Complexes with Chemically Modified/Single-Stranded Oligonucleotides and PEG-b-guanidinylated Polypeptides for Intracavity Encapsulation of Effector Enzymes Aimed at Cooperative Gene Knockdown.

2020

Beob Soo Kim
Mitsuru Naito
Hiroyuki Chaya
Mao Hori
Kotaro Hayashi
Hyun Su Min
Yu Yi
Hyun Jin Kim
Tetsuya Nagata
Yasutaka Anraku
Akihiro Kishimura
Kazunori Kataoka
Kanjiro Miyata

For the simultaneous delivery of antisense oligonucleotides and their effector enzymes into cells, nanosized vesicular polyion complexes (PICs) were fabricated from oppositely charged polyion-pairs...

Keywords:

Biophysics
Covalent bond
single stranded oligonucleotides
Gene knockdown
Effector
PEG ratio
RNase P
Encapsulation (computer programming)
Chemistry
Enzyme

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