The Influence of Perinatal Stressand Antidepressants on Different Types of Adaptive Behavior andCognitive Abilities of Prepubertal Female Rats
2020
We investigated the influence of repeated peripheral inflammatory
nociceptive stimulation of neonate female rats born to mothers exposed
during pregnancy to chronic stress and the effect of an antidepressant
drug fluoxetine, a selective serotonin (5-HT) reuptake inhibitor,
and an anxiolytic drug buspirone, a 5-HT1A receptor agonist, on
adaptive behavior and cognitive abilities of the offspring during
the prepubertal period. The data on the effect of maternal stress
exposure during the critical perinatal period of individual development
on adaptive behavior and spatial learning abilities of the offspring
provide support for the hypothesis on the possible beneficial effect
of moderate stressful events experienced at an early age on stress
tolerance in subsequent ontogenesis. The corrective effect of the
above drugs on adaptive behavior and cognitive abilities of the prenatally
stressed prepubertal female offspring exposed to repeated peripheral
inflammatory pain at the neonatal stage is characterized.
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