Identification and sequencing of the HLA-B*4106 allele

We report a novel HLA-B * 41 allele (HLA-B * 4106 initially detected by an unusual sequence-specific oligonucleotide (SSO) hybridization pattern and identified by sequence-based HLA typing. Molecular cloning and sequencing determined that the new HLA-B allele was identical to the HLA-B * 4101 in exon 2 and 3 except for a single nucleotide substitution in the exon 3 changing codon 204 from Glu to Gln (GAG→CAG). In addition, intron 2 was identical to the published HLA-B * 4104 intron 2, except for the base 509 (C→G).