Three new diterpenes and two new sesquiterpenoids from the endophytic fungus Trichoderma koningiopsis A729

Abstract Three new diterpenes koninginols A-C ( 1 – 3 ) and two new sesquiterpenoids 11-hydroxy-15-drimeneoic acid ( 4 ), koninginol D ( 5 ), together with twelve known compounds ( 6 – 17 ) were isolated from the endophytic fungus Trichoderma koningiopsis A729 derived from Morinda officinalis . Their structures were fully assigned with the aid of extensive spectroscopic analysis and reported data from the previous literatures. Koninginols A and B were disclosed as intriguing diterpene alkaloids, whereas the koninginol C was disclosed as one of the two examples of harziandione diterpene. All the isolates were evaluated for their antitumor activity, and compounds 1 – 2 , 4 – 6 , 11 – 13 , 16 – 17 were evaluated for their antibacterial activity, wherein the new compounds 1 and 2 exhibited significant antibacterial activity against Bacillus subtilis with MIC values of 10 and 2 μg/mL, respectively.