EVALUATION OF PHYSICOCHEMICAL PROPERTIES OF A TRADITIONAL THAI ANTIHYPERTENSIVE HERBAL RECIPE IN VARIOUS PREPARATIONS

Objective: The purpose of this article was to prepare a new suitable dosage form of a traditional Thai antihypertensive herbal recipe (TTAH). All details in a preformulation study and physicochemical properties of the preparations were reported. Methods: Three different formulations were prepared and evaluated for their physicochemical properties. The preformulation studies were investigated including angle of repose, bulk density, tapped density, Carr’s index, and Hausner ratio before further formulation.The appropriate formulations were evaluated in their physicochemical properties such as weight variation, friability, thickness, hardness, disintegration time, and content uniformity. Results: The C1 capsule contained 400 mg of herbal powder was the best dosage form because of its good results in physicochemical properties evaluation such as weight variation (489.2±10.84 mg), disintegration time (4.02±1.20 min), and content uniformity (piperine98.38±1.78%, imperatorin98.60±1.08%, and pinostrobin102.44±1.29%). Conclusion: Considering to formulation of the TTAH as a capsule, a tablet, or a pill, many parameters were evaluated. Pills and tablets failed on at least one criterion, with difficulties in manufacturing or disintegrating ability being recorded. Capsules passed all tested criteria and became the formulation of choice for TTAH.