Anti-TNFα alters the natural history of experimental Crohn's disease in rats when begun early, but not late, in disease

This study shows that anti-TNFα therapy decreased tissue inflammation and both proinflammatory and profibrotic cytokine gene expression when given early but not late in the course of peptidoglycan-polysaccharide (PG-PS)-induced enterocolitis. Hence this study provides a translational model that supports the clinical idea that anti-TNF therapy is most effective when begun early in the course of Crohn's disease.