A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

Robert J. Chambers,Kristin Abrams,Tessa A. Castleberry,John B. Cheng,Douglas A. Fisher,Ajith V. Kamath,Anthony Marfat,David O. Nettleton,Joann D. Pillar,Eben D. Salter,Alissa L. Sheils,John T. Shirley,Claudia R. Turner,John P. Umland,Kelvin Lam

A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

2006

Robert J. Chambers
Kristin Abrams
Tessa A. Castleberry
John B. Cheng
Douglas A. Fisher
Ajith V. Kamath
Anthony Marfat
David O. Nettleton
Joann D. Pillar
Eben D. Salter
Alissa L. Sheils
John T. Shirley
Claudia R. Turner
John P. Umland
Kelvin Lam

Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.

Keywords:

Eosinophil
Isozyme
Chemotaxis
Enzyme
Organic chemistry
Mechanism of action
Nicotinamide
Chemistry
Mediator
Biochemistry
Rolipram
Enzyme inhibitor

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