INFLUENCE OF THE N-MOM GROUP IN THE ENANTIOSELECTIVE LIPASE CATALYZED METHANOLYSIS OF RACEMIC 1,4-DIHYDROPYRIDINE DICARBOXYLATES

Abstract The hydrolysis of ( RS )-acetoxymethyl-ethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylates, N-methoxymethylated and N-unsubstituted has been carried out using lipases AK and PS from Pseudomonas . The presence of N-MOM changed the enantiopreference of lipase AK but not of lipase PS. The observed enantiopreference of the lipases is not changed by the nature of the organic solvent or the temperature.