Effect of Mulberry Leaves Extract on Mice Blood Glucose Level and the Mensuration of its Active Components

Using KM mouse as test animals,the effect of mulberry leaves extract(MLE) on blood glucose level was studied and the quantities of four components,named 1-deoxynojimycin(DNJ),flavone,polyphenol and polysaccharide were mensurated.The result showed that the MLE was able to inhibit the increase of blood glucose in diabetic model mice.When preparing MLE,there were remarkable differences among the mulberry varieties on the content of active components and the function of MLE in reducing the blood glucose level.Among the five tested mulberry varieties,the Shansang305 was the best one.Moreover,the optimum leaf order was the upper half of shoot from mulberry trees.There was a close relationship between the effect of MLE in reducing blood glucose and the content of DNJ.