Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.

Claudia A. Doege,Keiichi Inoue,Toru Yamashita,David B. Rhee,Skylar N. Travis,Ryousuke Fujita,Paolo Guarnieri,Govind Bhagat,William B. Vanti,Alan Shih,Ross L. Levine,Sara Nik,Emily I. Chen,Asa Abeliovich

Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.

2012

Claudia A. Doege
Keiichi Inoue
Toru Yamashita
David B. Rhee
Skylar N. Travis
Ryousuke Fujita
Paolo Guarnieri
Govind Bhagat
William B. Vanti
Alan Shih
Ross L. Levine
Sara Nik
Emily I. Chen
Asa Abeliovich

Parp1 and Tet2 mediate essential epigenetic remodelling events in an early phase of induced pluripotent stem cell reprogramming, thus directing subsequent induction of the pluripotency loci.

Keywords:

Nanog Homeobox Protein
Induced pluripotent stem cell
Stem cell
Reprogramming
Cell potency
DNA methylation
Somatic cell
Cancer research
Epigenetics
Biology
Homeobox protein NANOG
Genetics
KLF4
SOX2

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