Fluoropirrolidinas dipeptidyl peptidase inhibitors.

A compound of general formula (I): ** (See formula) ** selected from: (2S, 4S) -1 - [(2S) -2-amino-5- (4-fluorophenyl) -3, 3-dimethylpentanoyl] -4-fluoro-2-pyrrolidinecarbonitrile (2S, 4R) -1 - [(2S) -2-amino-4- (4-fluorophenyl) -3,3-dimethylbutanoyl] -4-fluoropirrolidin- 2-carbonitrile (2S, 4S) -1- (2R) -2-amino-3 - [(4-methoxybenzyl) thio] -3-methylbutanoyl] -4-fluoropyrrolidine-2-carbonitrile (2S, 4S ) -1 - {(2R) -2-amino-3-methyl-3 - [(3-phenylpropyl) thio] butanoyl} -4-fluoropyrrolidine-2-carbonitrile (2S, 4S) -1 - {(2R ) -2-Amino-3-methyl-3 - [(2-phenylethyl) thio] butanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - ((2R) -2-Amino-3 - {[3- (4-fluorophenyl) propyl] thio} -3-methylbutanoyl) -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-Amino-3 - [(4-methoxybenzyl) sulfonyl] -3-methylbutanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-Amino-3 - [(4-methoxybenzyl) sulfinyl] -3-metilbutanoi} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - ((2R) -2-Amino-3-methyl-3 - {[4- (trifluoromethyl) benzyl] thio} butanoyl) -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - [(2S) -2-Amino-2- (1-vinilciclopentil) ethanoyl] -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - [(2S) -2-Amino-5- (4-methoxyphenyl) -3,3-dimethylpentanoyl] -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-Amino-3-methyl-3 - [(3-phenylpropyl) sulfonyl] butanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-Amino-3-methyl-3 - [(4-methylbenzyl) sulfonyl] -4-fluoropyrrolidine butanoi}-2-carbonitrile; (2S, 4S) -1 - ((2R) -2-amino-3 - {[4- (benzyloxy) benzyl] sulfonyl} -3-methylbutanoyl) -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-amino-3 - [(4-cyanobencil) sulfonyl] -3-metilbutanoi} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - ((2R) -2-amino-3-methyl-3 - {[4- (methylsulfonyl) benzyl] sulfonyl} butanoyl) -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2S) -2-Amino-2- [1- (4-fluorobenzyl) cyclopentyl] ethanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - ((2S) -2-Amino-2- {1- [4- (trifluoromethyl) phenyl] cyclopentyl} ethanoyl) -4-fluoropyrrolidine-2-carbonitrile (2S, 4S ) -1 - {(2S) -2-Amino-2- [1- (4-fluorobenzyl) cyclopropyl] ethanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - [(2R) -2-Amino-3- (benzylsulfonyl) -3-methylbutanoyl] -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-amino-3 - [(3-methoxybenzyl) sulfonyl] -3-methylbutanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-Amino-3 - [(1,1 '- biphenyl-4-ylmethyl) sulfonyl] -3-methylbutanoyl} -4-fluoropyrrolidine-2-carbonitrile ; (2S, 4S) -1 - {(2R) -2-Amino-3 - [(2-methoxybenzyl) sulfonyl] -3-methylbutanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-Amino-3-methyl-3 - [(pyridin-3-ylmethyl) thio] butanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-Amino-3-methyl-3 - [(pyridin-2-ylmethyl) thio] butanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-Amino-3-methyl-3 - [(pyridin-4-ylmethyl) thio] butanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-amino-3 - [(4-fluorobenzyl) sulfonyl] -3-methylbutanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-amino-3-methyl-3 - [(3-phenoxybenzyl) sulfonyl] butanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-amino-3-methyl-3 - [(3-phenoxybenzyl) thio] butanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - ((2R) -2-Amino-3 - {[(5-chloro-1,1-dioxido-1-benzothien-3-yl) methyl] sulfonyl} -3-methylbutanoyl ) -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2R) -2-Amino-3 - [(2,1,3-benzoxadiazol-5-ylmethyl) thio] -3-methylbutanoyl} -4-fluoropyrrolidine-2-carbonitrile ; (2S, 4S) -1 - {(2R) -2-Amino-3-methyl-3 - [(pyridin-4-ylmethyl) sulfonyl] -4-fluoropyrrolidine butanoyl}-2-carbonitrile; (2S, 4S) -1 - [(2S) -2-Amino-3-pyridin-4-ylpropanoyl] -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - [(2S) -2-Amino-3-pyridin-3-ylpropanoyl] -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - [(2S) -2-Amino-3-piperidin-4-ylpropanoyl] -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - [(2S) -2-Amino-3-piperidin-3-ylpropanoyl] -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - [(2S) -2-Amino-3-piperidin-2-ylpropanoyl] -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2S) -2-Amino-3- [1- (isopropylsulfonyl) piperidin-4-yl] propanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2S) -2-Amino-3- [1- (4-methylphenylsulfonyl) piperidin-4-yl] propanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2S) -2-Amino-3- [1- (isopropylsulfonyl) piperidin-3-yl] propanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - {(2S) -2-Amino-3- [1- (4-methylphenylsulfonyl) piperidin-3-yl] propanoyl} -4-fluoropyrrolidine-2-carbonitrile; (2S, 4S) -1 - [(2S) -2-Amino-3- (1-benzothien-3-yl) propanoyl] -4-fluoropyrrolidine-2-carbonitrile; and (2S, 4S) -1 - {(2S) -2-amino-3-methyl-3- [4- (trifluoromethyl) phenyl] -4-fluoropyrrolidine butanoyl}-2-carbonitrile.