Enzymatic syntheses of 6-(4H-Selenolo[3,2-b]pyrrolyl)-L-alanine, 4-(6H-selenolo[2,3-b]pyrrolyl)-L-alanine, and 6-(4H-furo[3,2-b]pyrrolyl)-L-alanine

Abstract 6-(4H-Selenolo[3,2- b ]pyrrolyl)-L-alanine 1 , 4-(6H-selenolo[2,3- b ]pyrrolyl)-L-alanine 2 , and 6-(4H-furo[3,2- b ]pyrrolyl)-L-alanine 3 have been synthesized via reactions of selenolo[3,2- b ]pyrrole, selenolo[2,3- b ]pyrrole, and furo[3,2- b ]pyrrole, respectively, with L-serine. The reactions are catalyzed by Salmonella typhimurium tryptophan synthase.