Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system

Tingting Yuan,Yi Zhong,Yingge Wang,Ting Zhang,Rui Lu,Minya Zhou,Yaoyao Lu,Kunning Yan,Yajie Chen,Zhehui Hu,Jingyan Liang,Jianglin Fan,Yong Cheng

Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system

2019

Tingting Yuan
Yi Zhong
Yingge Wang
Ting Zhang
Rui Lu
Minya Zhou
Yaoyao Lu
Kunning Yan
Yajie Chen
Zhehui Hu
Jingyan Liang
Jianglin Fan
Yong Cheng

Objective To generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study of hyperlipidemic and atherosclerosis.

Keywords:

Genetics
CRISPR
Gene
Internal medicine
Apolipoprotein E
Apolipoprotein B
Endocrinology
Genome editing
Biology
LDL receptor
Hyperlipidemia
Clinical chemistry
Lipidology
Lipoprotein
Blot

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