Spectroscopic, potentiometric and theoretical studies of novel imino-phenolate chelators for Fe(III).

Abstract The present study was targeted to explore the binding properties of two strong chelators for Fe(III) based on tripodal-iminophenolate moiety. Complexation behavior of the tripodal systems cis – cis cyclohexane-1,3,5-tricarboxylic acid tris-({2-[(2-hydroxy-benzylidene)-amino]-ethyl}-amide (CYCOENSAL, L 1 ) and cis – cis cyclohexane-1,3,5-tricarboxylic acid tris-({3-[(2-hydroxy-benzylidene)-amino]-propyl}-amide (CYCOPNSAL, L 2 ) is described. Three protonation constants obtained are assigned for three hydroxyl groups of aromatic ring were employed for the evaluation of the formation constants of the metal complexes. Both ligands liberate three protons each forming monomeric complexes of type FeLH 3 , FeLH 2 , FeLH and FeL (L = L 1 and L 2 ). The first species FeLH 3 depicted at low pH, where the ligands were coordinated through three imine nitrogen and other species form subsequently from FeLH 3 in steps upon deprotonation and coordination of the phenolic oxygen giving encapsulated tris(phenolate) complexes. The probable structures of the metal complexes formed in solution were proposed through molecular modeling calculations. L 2 was observed to be highly selective towards Fe(III) as compared to L 1 .