Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1

A 3.9-A-resolution cryo-EM structure of the S. cerevisiae OCCM replicative helicase loading complex bound to DNA shows how ORC and Cdc6 recognize DNA origins, and reveals details of how the Mcm2–7 hexamer ring is loaded onto the DNA helix.