Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity

Yanqin Yu,Xianbo Zuo,Miao He,Jinping Gao,Yuchuan Fu,Chuanqi Qin,Liuyan Meng,Wenjun Wang,Yaling Song,Yong Cheng,Fusheng Zhou,Gang Chen,Xiaodong Zheng,Xinhuan Wang,Bo Liang,Zhengwei Zhu,Xiazhou Fu,Yujun Sheng,Jiebing Hao,Zhongyin Liu,Hansong Yan,Elisabeth Mangold,Ingo Ruczinski,Jianjun Liu,Mary L. Marazita,Kerstin U. Ludwig,Terri H. Beaty,Xuejun Zhang,Liangdan Sun,Zhuan Bian

Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity

2017

Non-syndromic cleft lip with palate is a common birth defect of unknown aetiology. Here, the authors discover 14 new genes associated with this condition, and show genetic heterogeneity in this and other non-syndromic orofacial clefting disorders.

Keywords:

Genetic heterogeneity
Genetics
Locus (genetics)
Genome
Gene
Biology
Genome-wide association study
TFAP2A
Single-nucleotide polymorphism
Genetic predisposition
Craniofacial
PTCH1

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