Effect of epidermal chalones on induction and growth of tumors of the cervicovaginal epithelium in mice

During induction of tumors of the cervicovaginal epithelium by means of dimethylbenzanthracene in female BALB/c mice or after their appearance, a 1% solution of chalones contained in 55–81% ethanol extracts of rat skin or liver (control) was applied intravaginally. The use of skin extract during induction of tumors, but not the use of liver extract, was shown to retard growth of tumors of the vagina and cervix uteri a little and to reduce the frequency of their appearance; as a result of their action on neoplasms already formed in this situation the chalones prolonged the survival of the animals with tumors.