Advance in the Application of Polymyxin B

Polymyxin B(PMB) has both abilities of antibacteri and antiendotoxin.Since antibacterial action was played through the interaction of PMB and LPS in cell wall,PMB have re-emerged in clinical practice owing to the increasing prevalence of nosocomial infections caused by multidrug-resistant Gram-negative bacteria.However,the pharmacokinetics,pharmacodynamics and toxicodynamics of polymyxin B and its efficacy alone and in combination with other antibiotics are not defined.Thus,optimized dosage regimens are not known yet.Direct hemoperfusion using The polymyxin B immobilized fiber column(PXB),which was applied to the treatment of sepsis and shock to removal endotoxin,has showed good results.But many of the analyzed studies were of suboptimal quality such as lacking of control group.The PXB needs to be detail studied,and can be used to remove ednotoxin in the production of chemicals and biological products which were susceptible to endotoxic contamination.