Expression of ERBB2 in gastric carcinomas : relationship between p185ERBB2 expression and the gene amplification

The expression of p185 ERBB2 in a total of 34 human gastric carcinoma tissues as well as in corresponding normal mucosa was examined by Western blotting. More than 70% of both tumor tissues and normal mucosa showed p185 ERBB2 expression at various levels. Eighteen (55%) cases revealed higher levels of p185 ERBB2 in the tumor than in normal mucosa, while 13 (38%) cases showed lower levels in the tumor tissues