Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life

Brian C. Mackness,Julie Jaworski,Ekaterina Boudanova,Anna Park,Delphine Valente,Christine Mauriac,Olivier Pasquier,Thorsten Schmidt,Mostafa Kabiri,Abdullah Kandira,Katarina Radosevic,Huawei Qiu

Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life

2019

Brian C. Mackness
Julie Jaworski
Ekaterina Boudanova
Anna Park
Delphine Valente
Christine Mauriac
Olivier Pasquier
Thorsten Schmidt
Mostafa Kabiri
Abdullah Kandira
Katarina Radosevic
Huawei Qiu

ABSTRACTThe neonatal Fc receptor (FcRn) promotes antibody recycling through rescue from normal lysosomal degradation. The binding interaction is pH-dependent with high affinity at low pH, but not u...

Keywords:

Immunology
Half-life
Molecular biology
Antibody
Neonatal Fc receptor
Biology
ph dependence
Mutagenesis

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