Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia

Leopold Garnar-Wortzel,Timothy R. Bishop,Seiya Kitamura,Natalia Milosevich,Joshua N. Asiaban,Xiaoyu Zhang,Qinheng Zheng,Emily Chen,Anissa R. Ramos,Christopher J. Ackerman,Eric Hampton,Arnab K. Chatterjee,Travis S. Young,Mitchell V. Hull,K. Barry Sharpless,Benjamin F. Cravatt,Dennis W. Wolan,Michael A. Erb

Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia

2021

Leopold Garnar-Wortzel
Timothy R. Bishop
Seiya Kitamura
Natalia Milosevich
Joshua N. Asiaban
Xiaoyu Zhang
Qinheng Zheng
Emily Chen
Anissa R. Ramos
Christopher J. Ackerman
Eric Hampton
Arnab K. Chatterjee
Travis S. Young
Mitchell V. Hull
K. Barry Sharpless
Benjamin F. Cravatt
Dennis W. Wolan
Michael A. Erb

Transcriptional coregulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic...

Keywords:

Gene expression
Cell biology
Small molecule
Chemistry
Acute leukemia
chemical inhibition

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