Association of STAT3 and STAT4 polymorphisms with susceptibility to chronic hepatitis B virus infection and risk of hepatocellular carcinoma: a meta-analysis
2019
Background:It has been reported that polymorphisms of
signal transducer and
activator of transcription (STAT
)
3 and
STAT4 might be associated with susceptibility to hepatitis B virus (HBV) infection and risk of chronic hepatocellular carcinoma (HCC). Owing to limitation of sample size and inconclusive results, we conducted a meta-analysis to clarify the association. Methods: We identified relevant studies by a systematic search of Medline/PubMed, EMBASE, Web of Science and the Cochrane Library through Feb.20.2019. The strength of the association measured by odds ratios (OR) with 95% confidence intervals (CIs) was studied. All the statistical analyses were conducted based on Review manager 5.3 software. Results:A total of 5242 cases and 2717 controls from 5 studies were included for the
STAT3 polymorphism, 5902 cases and 7867 controls from 9 studies for the
STAT4 polymorphism. Our results suggested that
STAT3 rs1053004 polymorphism was a significant risk factor of chronic HBV infection (C vs. T: OR = 1.17, 95% CI: 1.07-1.29, P A = 0.0007; CC + CT vs. TT: OR = 1.38, 95% CI: 1.09-1.76, P A =0.008). Validation with all the genetic models revealed that rs7574865 polymorphism of
STAT4 gene was closely associated with chronic HBV infection (P A A
STAT3 rs1053004 polymorphism may be the risk for developing chronic HBV infection but not associated with HCC. The present study also indicates that
STAT4
rs7574865 polymorphism increased the risk of chronic HBV infection and HCC.
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