THE INTERACTION OF BIS[2-MERCAPTOETHANESULFONATO (2−)-Sl, BIS[L-CYSTEINATO(1−)-S], AND BIS[L-PENICILLAMINATO(1−)-Sl- DIMETHYLTIN (IV), WITH RAT HEMOGLOBIN: A119Sn MöSSBAUER SPECTROSCOPIC STUDY

Abstract The title compounds, representative of classes of diorganotin (IV) derivatives active against murine leukemia P-388. interact with rat hemoglobin (selected as a model protein) by: i) co-crystallization. with formation of microcrystalline pellets, and: ii) diffusion into hemoglobin crystals from the supernatant solution (as determined for the 2-mercaptoethanesulfonato derivative). The nature of the Me2SnIV species in hemoglobin has been investigated by 119Sn Mossbauer spectroscopy, and a C2SnS2 tetrahedral geometry has been assigned by the point-charge model rationalization of the nuclear quadrupole splitting parameter. Binding into crystalline hemoglobin has been ascribed to Coulomb interactions and to hydrogen bonding between the sulfonate and the aminoacid tails of the organotin (IV) derivatives and functional groups of the globin.