Enolate‐Mediated 1,3‐Dipolar Cycloaddition Reaction of β‐Functionalized Ketones with Nitrile Oxides: Direct Access to 3,4,5‐Trisubstituted Isoxazoles.

TMG-catalyzed [3 + 2] organocatalytic 1,3-dipolar cycloaddition reactions of β-functionalized ketones with nitrile oxides have been developed. This strategy could generate 3,4,5-trisubstituted isoxazoles in high yields and regioselectivities.