Microwave induced synthesis, and pharmacological properties of novel 1-benzoyl-4-bromopyrrolo[1,2-a]quinoline-3-carboxylate analogues

Abstract Eco-friendly methods of heterocyclic synthesis are highly important in view of pharmacology. This synthetic chemistry deals with the application of environmental friendly chemical compounds synthesis using microwave methods. Greener method of synthesis of benzo-fused indolizines like ethyl 4-Bromo-1-(substituted-benzoyl)pyrrolo[1,2-a]quinoline-3-carboxylate analoguos 1a-n using the one-pot method with 3-bromo quinolone, phenacyl bromide and electron-deficient alkynes in the presence of triethylamine base with acetonitrile as a solvent. The structures of all the newly synthesized pyrrolo[1,2-a]quinoline have been confirmed by spectroscopic techniques. All the synthesized test compounds were screened for their antibacterial activity using six different types of gram-positive and gram-negative bacterial strains. The compounds 1a, 1k, and 1l exhibited a significant zone of inhibition against all six bacterial strains, and the test compound 1i showed potent free radical scavenging activity with the highest percentage inhibition of 49.27 at 100 µg/mL.