Pyrrolidone and pyrazole compounds and their use as medicaments

The present invention belongs to the field of medical technology. The present invention provides a pyrrole-based compounds, including optical isomers, racemates, cis and trans isomers or any combination thereof, and a pharmaceutically acceptable salt thereof, as structural formula (Ⅰ) FIG. Compounds of the invention may be as small molecule inhibitors of the interaction of p53-MDM2 / X protein. Compounds of the invention may be used for preparing anti-tumor or anti-inflammatory drugs.