CuCN catalyzed one pot synthesis of γ-keto diesters: domino double Michael addition followed by Nef reaction
2012
Abstract An efficient one pot synthesis of γ-keto diesters through double Michael addition coupled with Nef reaction in the presence of CuCN catalyst and Cs 2 CO 3 base is described. The reaction proceeds rapidly in DCM to give the products in good yields. A plausible mechanism is proposed.
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