Synthesis of Marine C2-Symmetrical Macrodiolide Natural Products

Marine natural products play a pivotal role in the discovery of structurally novel and diverse compounds with the unique pharmacological profiles. The marine C2-symmetrical macrodiolides belong to a relatively small group in marine natural products, but most of them exhibit various different biological activities and possess a fascinating structure. In this review, the total syntheses and the synthetic studies of C2-asymmetrical macrodiolides, swinholide A, clavosolide A, cyanolide A, marinomycin A will be discussed. All marine natural products shown here are potential candidates for drug discovery and drug lead.