Histological study on acute inflammatory reaction to polyurethane-coated silicone implants in rats 1 Estudo histológico da reação inflamatória aguda ao implante de silicone revestido com poliuretano em ratos

Purpose: Evaluating histologically the silicone peri-implant coated by polyurethane inflammation associated to the use of anti-microbial and bacterial contamination. Methods: It was used 35 Wistar rats. The animals were divided in seven groups: I — Control; II — implant cavity contamination with10 bacteria/ml; III - implant cavity contamination with 10 bacteria/ml; IV — implant cavity contamination with 10 bacteria/ml; V — identical contamination to group II and implant immersions in anti-microbial solution; VI — identical contamination in group III and implant immersions in the anti-microbial solution; VII — identical contamination of group IV and implant immersions in anti-microbial solution. It was evaluated morphometrically the peri-implant capsules after 30 days of introduction. Results: The factors with more discriminating power were the giants cells of a strange body and the mononuclear. There was no correlation between the bacterial concentrations and the histological alterations. Conclusion: 1) The histological standard of the inflammatory reaction around the silicone implant