Biphenyl derivatives as agonists beta2 adrenoceptor antagonists RECEIVERS AND muscarinic receptor

CONCERNS biphenyl derivatives of formula I wherein a and b are 0-3; c is 0-4; R1 is C1-C4 alkyl, C2-C4, C2-C4, among others; R2 is C1-C4 alkyl, C2-C4, among others; W is attached at the 3 or 4 relative to N in the piperidine ring and is 0 or Nwa; Wa is H or alkyl C1-C4; R3 is C1-C4 alkyl, C2-C4, C2-C4, among others; R4 is a divalent group of formula (R4a) d- (A1) e- (R4b) g- (A2) h- (R4d) i, wherein d, e, f, g, h 0 or 1; R4a, R4b, R4c and R4d ARE C1-C10, C2-C10 or C2-C10 alkynylene, among others; A1 and A2 are C3-C7 cycloalkylene, arylene C6-C10, O-C6-C10 arylene, among others; Q is a bond, C (O) O, OC (O), S, among others; R5 is H or alkyl C1-C4; R6 is NR6aCR6b (O) or CR6cR6dOR6e; R7 is H; or R6 and R7 together form NR7aC (O) -CR7b = CR7c; CR7d = CR7E-C (O) -NR7f, among others; R6a, R6b, R6c, R6d, R6e, R7a, R7b, R7c, R7d, R7e R7f Y are H or alkyl C1-C4. Preferred compounds: 1-biphenyl-2-YL-3- (1- {9- [2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinoline-5-yl) ethylamino] nonyl} piperidin-4-yl) -urea; Ditrifluoroacetate 1- {9- [2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinoline-5-yl) ethylamino] nonyl} piperidin-4-YL ESTER ACID biphenyl-2-ylcarbamic ; AMONG OTHERS. ALSO it INVOLVES A PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION. These compounds are adrenoceptor agonists and antagonists b2 muscarinic and are useful for treating LUNG