Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells

Xiaopeng Li,Heather Rayford,Ruijie Shu,Jiaju Zhuang,Bruce D. Uhal

Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells

2004

Xiaopeng Li
Heather Rayford
Ruijie Shu
Jiaju Zhuang
Bruce D. Uhal

Our earlier studies showed that bleomycin-induced apoptosis of type II alveolar epithelial cells (AECs) requires the autocrine synthesis and proteolytic processing of angiotensinogen into ANG II an...

Keywords:

Cathepsin D
Autocrine signalling
Fibrosis
Programmed cell death
Apoptosis
Lung
Biology
Biochemistry
Epithelium
Molecular biology
Bleomycin
lung injury

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